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Astrocytoma pathology outlines

Pathology Outlines - Diffuse astrocytoma IDH mutan

Definition / general IDH1 / 2 mutated well differentiated diffusely infiltrating glioma with astrocytic features without 1p / 19q codeletion and usually with p53 and / or ATRX mutations In the absence of 1p / 19q codeletion, a component morphologically resembling oligodendroglioma is compatible with this diagnosi See also Diffuse astrocytoma, IDH-mutant, Diffuse astrocytic and oligodendroglial tumors-General; Tumor morphologically conforming with diffuse astrocytoma but in which IDH testing is not available or cannot be fully performed Modifier not otherwise specified (NOS) does not refer to a specific entity; it simply indicates that the case requires additional molecular workup (Acta Neuropathol. Pilocytic astrocytoma: pathology, molecular mechanisms and markers Pilocytic astrocytomas (PAs) were recognized as a discrete clinical entity over 70 years ago. They are relatively benign (WHO grade I) and have, as a group, a 10-year survival of over 90% Anaplastic astrocytoma, IDH wildtype: anaplastic astrocytoma lacking IDH mutation; negative R132H-IDH1 immunohistochemistry is insufficient for this diagnosis as IDH1 / 2 sequencing must be performed for a wildtype diagnosis Anaplastic astrocytoma, NOS: when the tumor shows classical anaplastic astrocytoma histology but molecular studies to confirm IDH mutation are lacking, or are inconclusiv

An astrocytoma is a neoplasm derived from an astrocyte. Diffuse astrocytomas are common glial tumours and grouped together with Oligodendroglioma in the current WHO brain tumor classficiation Diffuse astrocytoma (AKA: diffuse, low-grade astrocytoma) is a infiltrating astrocytoma occurring in the CNS white matter. Most common grade II WHO glioma in adults (peaks between 30-40 years). 10-15% of all astrocytomas. Usually shows progression to glioblastoma sooner or later pathology of glioblastoma, astrocytoma, and oligodendroglioma. Diffuse astrocytomas are most frequent in young adults. They arise anywhere in the CNS, but are most frequent in the cerebral hemispheres, especially frontal lobes Anaplastic astrocytoma (AKA: high-grade astrocytoma) is a infiltrating neoplasm of the diffuse astrocytic and oligodendroglial tumor group occurring in the CNS white matter. Most common grade III WHO glioma in adults (peaks between 40-50 years). Approx 5% of all gliomas. Usually shows progression to glioblastoma sooner or later

Diffuse (Fibrillary) Astrocytoma. Reviewer (s): Dharam M. Ramnani, M.D. Home Neuropath Glial Tumors Diffuse (Fibrillary) Astrocytoma. Notes: This is a listing of diffuse astrocytomas. Fibrillary Astrocytoma, WHO Grade II. Fibrillary Astrocytoma, WHO Grade II. Fibrillary Astrocytoma, WHO Grade II. Low-grade Astrocytoma : CT Scan This astrocytoma demonstrates increased cellularity and pleomorphism, as compared to normal brain. Note the very pleomorphic cell in the center. Tutorial contains images and text for pathology educatio Pleomorphic xanthoastrocytoma Pleomorphic xanthoastrocytoma, abbreviated PXA, is neuropathology tumour classically associated with seizures in children

Abstract Background: Granular cell astrocytoma (GCA) is an aggressive variant of astrocytoma characterized by predominantly round-to-polygonal cells with abundant eosinophilic granular cytoplasm Subependymal giant cell astrocytoma - Libre Pathology Subependymal giant cell astrocytoma Subependymal giant cell astrocytoma, abbreviated SEGA, is a low-grade astrocytoma associated with tuberous sclerosis complex PILOCYTIC ASTROCYTOMA-WHO GRADE I Pilocytic astrocytoma (PA) is a biologically and histologically distinct form of astrocytoma of children and young adults and is the most frequent BT in children. Most PAs arise in the cerebellum, hypothalamus, and optic chiasm. Some arise in the cerebral hemispheres and other locations Low-grade astrocytoma - WHO Grade I by definition, but rare anaplastic forms have been described. Classically in the cerebellum in children; most common glioma in children. The optic glioma is associated with neurofibromatosis 1. Rare variants include Pilomyxoid astrocytoma and Anaplastic pilocytic astrocytoma. Imaging. Well-defined, T2. Pilocytic astrocytoma: pathology, molecular mechanisms and markers. Pilocytic astrocytoma, Brain neoplasms, Histopathology, Morphology On cross section, the optic nerve outline is often visible near the center of the specimen, while the tumor characteristically grows in the subarachnoid space between the nerve and the.

Pathology Outlines - Diffuse astrocytoma, NO

General Discussion Anaplastic astrocytoma is a rare malignant brain tumor. Astrocytomas are tumors that develop from certain star-shaped brain cells called astrocytes. Astrocytes and similar cells form tissue that surrounds and protects other nerve cells found within the brain and spinal cord The pathology report states the type of tumor and the grade of the tumor. An additional part of the astrocytoma cells, which are glioblastoma, or fast-growing, aggressive tumor cells. If your tumor is an help outline vital parts of the brain to be avoided during surgery. Lasers and tiny microscopic instruments may b

Pilocytic astrocytoma: pathology, molecular mechanisms and

Visual survey of surgical pathology with 11145 high-quality images of benign and malignant neoplasms & related entities. Focused Pilocytic Astrocytoma with stained slides of pathology. Follow us: 11145 Images : Last Website Update : Jun 9, 2021. Pilocytic Astrocytoma. Tutorial contains images and text for pathology education. Here is a pilocytic astrocytoma (juvenile, or cystic, astrocytoma) of the cerebellum in a child. This neoplasm typically is composed of a large cyst with a mural nodule of solid tumor. Most childhood brain tumors arise below the tentorium, which is the reverse of the adult Posted on July 7, 2020 July 6, 2020 Author pathologyoutlinesblog Categories Image Quiz Tags Anaplastic astrocytoma, Image Quiz, micro images, pathology, Pathology Outlines, pathologyoutlines, pathologyoutlines.com Leave a comment on 7 July 2020: Image Quiz #34 23 June 2020: Biweekly Image Quiz #3 PROX1 is a prospero-related transcription factor that plays a critical role in the development of various organs including the mammalian lymphatic and central nervous systems; it controls cell proliferation and differentiation through different transcription pathwaysand has both oncogenic and tumor-

Video: Pathology Outlines - Anaplastic astrocytoma, IDH mutan

Comments: Gemistocytic astrocytoma is a low-grade astrocytoma with poorer prognosis than other WHO grade matched tumors. They show a higher rate of progression to glioblastoma and some authors suggest they should be considered WHO Grade III tumors. The histologic hallmark is the presence of gemistocytes - large tumor cells with abundant dense eosinophilic, GFAP-positive cytoplasm displacing. Pathophysiology. SEGA vs. SGTC: SEGA is most commonly known as the brain neoplasm associated with TSC (18, 24, 28).Historically, these tumors were considered to be astrocytomas. Recently, SEGA has been called subependymal giant cell tumor (SGTC) because the cells of the tumor can be of mixed types, rather than being restricted to astrocytes.Both terms, SGTC and SEGA, are used in the medical. Useful for differentiating astrocytoma vs. oligodendroglioma. H3K27me3 -ve (nuclear loss). SOX10 +ve (up to 80%). p53 -ve or low expressed. Ki-67 (usu. >5% in grade II). May have neuronal islands (Synapto +ve, NeuN +ve). Molecular pathology. Combined losses of 1p and 19q both and presence of IDH1/2 mutation is required for final diagnosis.

Astrocytoma - Libre Patholog

  1. Astrocytoma is the most common a type of glioma tumor that can develop in the brain and spinal cord. It's more common in men than women and most often shows up after age 45. There are several.
  2. Astrocytoma originates in astrocytes, which are a kind of glial cells in the cerebrum which are star-shaped. It is the most common glioma, usually affecting the brain and sometimes the spinal cord. Amongst brain tumors, glial tumors comprise 60% of the tumors. They are a common cause of mortality and morbidity in both the young and old
  3. The pathology report states the type of tumor and the grade of the tumor. An additional part of the astrocytoma cells, which are glioblastoma, or fast-growing, aggressive tumor cells. If your tumor is an help outline vital parts of the brain to be avoided during surgery. Lasers and tiny microscopic instruments may b
  4. This review outlines the clinical, genetic, immunologic, and histopathologic characteristics of astrocytic tumors in dogs with special focus on comparative neuro-oncology. Common problems associated with the diagnosis of these neoplasms are summarized. Astrocytoma / pathology Astrocytoma / veterinary* Brain Neoplasms / metabolism.

Diffuse astrocytoma - Libre Patholog

Glial tumors - Neuropatholog

Pilomyxoid astrocytoma is a variant of pilocytic astrocytoma and the clinical, histological and molecular data point to a very close relationship as well as a more aggressive biological behavior for the former. WHO 2016 classification does not provide a specific grade for these neoplasms, but there Leukocytoclastic vasculitis is a vasculitis of the small vessels and is also described as a hypersensitivity vasculitis.. Histology of leukocytoclastic vasculitis. Low power view of leukocytoclastic vasculitis gives the pattern of a busy dermis with a superficial and mid perivascular inflammatory pattern (Figure 1). There is a population of predominantly neutrophils in a perivascular and. Pathophysiology. Astrocytoma causes regional effects by compression, invasion, and destruction of brain parenchyma, arterial and venous hypoxia, competition for nutrients, release of metabolic end products (e.g., free radicals, altered electrolytes, neurotransmitters), and release and recruitment of cellular mediators (e.g., cytokines) that disrupt normal parenchymal function Pleomorphic xanthoastrocytoma (PXA) is an uncommon, usually low-grade, astrocytic tumor. Characteristic histological features include tumor cell pleomorphism and lipidization of tumor cells. Albeit prognosis in PXA is generally good, cases with histological signs of anaplasia have been observed. In The anaplastic astrocytoma (grade III) represents an intermediate stage in the progression of diffuse astrocytoma to glioblastomas both histologically and in molecular features. As an intermediate stage of a biologic spectrum, there is some controversy over the histologic landmarks that identify this tumor

Pathology. Fibrillary astrocytomas arise from neoplastic astrocytes, a type of glial cell found in the central nervous system. They may occur anywhere in the brain, or even in the spinal cord, but are most commonly found in the cerebral hemispheres. As the alternative name diffuse astrocytoma implies, the outline of the tumour is not clearly. Anaplastic astrocytoma is a rare, cancerous (malignant) type of brain tumor that arises from star-shaped brain cells called astrocytes. These cells surround and protect nerve cells in the brain and spinal cord. An anaplastic astrocytoma usually develops slowly over time, but may develop rapidly

Pilocytic astrocytoma (PCA), previously known as cystic cerebellar astrocytoma or juvenile pilocytic astrocytoma, was first described in 1931 by Harvey Cushing, based on a case series of cerebellar astrocytomas; though he never used these terms but rather described a spongioblastoma.[1] They are low-grade, and usually well-circumscribed tumors, which tend to occur in young patients Clinical Features. The overall incidence of pilocytic astrocytomas is 0.31 per 100,000 persons per year. They constitute 23.5% of pediatric central nervous system (CNS) tumors and are the most common variant of glioma in children. [] The tumors most frequently affect persons in the first 2 decades of life when the age-specific incidence rises to 0.70 per 100,000 persons per year. [ anaplastic astrocytoma pathology pathology in outline format with mouse over histology previews

Anaplastic astrocytoma - Libre Patholog

Occasionally pathology is positive for grade II fibrillary astrocytoma. These tumors are slow growing and are not generally associated with metastatic deposits. High grade lesions are very rare in children. The suggested precursor cell is the 02A cell, a glial precursor present in the optic pathway Glioblastoma (GBM), also referred to as a grade IV astrocytoma, is a fast-growing and aggressive brain tumor.It invades the nearby brain tissue, but generally does not spread to distant organs. GBMs can arise in the brain de novo or evolve from lower-grade astrocytoma. In adults, GBM occurs most often in the cerebral hemispheres, especially in the frontal and temporal lobes of the brain

pilocytic astrocytoma pathology pathology in outline format with mouse over histology previews The central nervous system (CNS) is the most common site of primary solid tumors in pediatric population. Among pediatric patients (age 0-19 years), pilocytic astrocytoma (PA) is the most prevalent CNS tumor, representing 19.7% of all cases and accounting for an approximate of 5-6% of all gliomas.[] This neoplasm can occur at all levels of the neuraxis, with majority (67%) arising in the.

Tutorial contains images and text for pathology education. Astrocytomas can range from low grade to high grade. Seen here is the highest grade and the worst possible form of glioma--a glioblastoma (previously glioblastoma multiforme). They occur in adults. Glioblastomas are quite vascular with prominent areas of necrosis and hemorrhage Intermediate Filaments and GFAP. A deeper understanding of Rosenthal fibers is greatly facilitated by an appreciation of the cytoskeletal architecture of the typical astrocyte. Throughout the body, eukaryotic cellular integrity depends upon 3 protein networks that include the actin microfilaments (5-7 nm in diameter), the microtubules (20. Terminology. Unlike the other variants of diffuse low grade gliomas (e.g. gemistocytic astrocytoma, protoplasmic astrocytoma, oligoastrocytoma) or the focal low grade gliomas (e.g. pilocytic astrocytoma, subependymal giant cell astrocytoma) they are often merely referred to as a low grade glioma. Epidemiology. Typically patients diagnosed with low grade infiltrative astrocytomas are young. Small cell astrocytoma is an aggressive histologic variant that behaved like primary GBM, even in the absence of endothelial hyperplasia and necrosis. Despite considerable morphologic overlap with anaplastic oligodendroglioma, clinicopathologic and genetic features were distinct Paul E. McKeever, in Diagnostic Immunohistochemistry (Third Edition), 2010 Gemistocytic Astrocytoma (WHO Grade II) Gemistocytes are cells swollen with hyaline, pink cytoplasm that is reactive for GFAP (Fig. 20.15 A; see Table 20.5).Their hyperchromatic and angulated nuclei are at the rim of the cells, producing a bizarre caricature of a reactive astrocyte

Diffuse (Fibrillary) Astrocytom

Cancer cells can also be found in other structures of the brain: neurons, secretory cells that produce hormones, brain membranes, and even blood vessels. But glial cell tumors remain the most common variant of brain cancer, diagnosed in 45-60% of cases of this terrible disease. In this case, about 35-40% falls on astrocytoma of the brain Pilocytic astrocytoma: pathology, molecular mechanisms and markers On cross section, the optic nerve outline is often visible near the center of the specimen, while the tumor characteristically grows in the subarachnoid space between the nerve and the dural sheath that is markedly expanded. WebPathology is a free educational resource with 11144 high quality pathology images of benign and malignant neoplasms and related entities Pilocytic astrocytomas are tumors of young people, with 75% occurring in the first two decades of life, typically late in the first decade (9-10 years). There is no recognized gender predisposition. Although only accounting for between 0.6-5.1% of all intracranial neoplasms (1.7-7% of all glial tumors) they are the most common primary brain.

CNS Pathology - University of Uta

A juvenile pilocytic astrocytoma (JPA) is a slow-growing brain tumor that develops — usually in children and adolescents — from cells called astrocytes. Astrocytes are glial cells, meaning that they are a type of cell that supports nerve cells in the brain and spinal cord, so a juvenile pilocytic astrocytoma is a kind of glioma. Unlike other gliomas, though, juvenile pilocytic astrocytomas. Pathology of brain tumors-D r Amit Thapa Astrocytoma 985 21% Oligodendroglioma 238 5% Ependymoma 170 4% Mixed glioneuronal tumor 72 1% Embryonal type 164 3% Pineal tumors 19 0% Others 2418 51% Meningioma 577 12% Lymphoma 58 1% Germ cell Tumor 23 0% Hemangiopericytoma 46 1% Hemangioblastoma 61 1% Melanoma 5 0% n= 5076 patients Glioblastoma, also.

Introduction. Pilomyxoid astrocytoma (PMA) is an uncommon progressive piloid neoplasm, closely related to pilocytic astrocytoma (PA).[] Originally described by Janisch et al.,[] in 1985 as 'diencephalic pilocytic astrocytoma with clinical onset in infancy', the term pilomyxoid astrocytoma was introduced in 1999 by Tihan et al.[] It has been recognized as a separate entity in WHO. Pathology of intracranial tumors lecture. 1. Pathology of intracranial tumours- a primer E.E.U. AKANG, MBBS, FMCPath, FWACP Consultant Pathologist, Department of Pathology, University College Hospital, Ibadan, Nigeria National Postgraduate Medical College of Nigeria 2014 Revision Course in Pathology FEBRUARY 14, 2014 LAGOS, NIGERIA. 2 The WHO grading system is the most widely used system for grading diffuse astrocytomas (at the time of writing i.e. mid-2016) and is an adaptation of the now superseded St Anne-Mayo grading system (also known as the Daumas-Duport grading system).. Grade I is reserved for localized astrocytomas (see WHO classification of CNS tumors for a complete list) and as such diffuse astrocytomas range in. Pilocytic astrocytoma is a rare type of brain tumor that occurs mostly in children and young adults under age 20. The tumor rarely occurs in adults. The tumor rarely occurs in adults

Pleomorphic xanthoastrocytoma - Libre Patholog

Ependymoma. of the 4th ventricle. Ependymomas are predominantly tumors of children and adolescents. They arise most frequently in the fourth ventricle and cause hydrocephalus by blocking CSF flow. However, they may occur anywhere in relation to the ventricular system or central canal of the spinal cord and are the most common primary intra. Pilocytic astrocytoma is the most common childhood brain tumor and most often found in the posterior fossa. Complete resection usually cures the patient; however, the patient can present with brainstem compression and hydrocephalus, which are both potentially life-threatening. Therefore, it is essential to achieve early diagnosis and treatment

Pathology. Hemangioblastoma is actually a capillary hemangioma and, despite the name with the affix of blastoma, it is a low grade (WHO grade I) lesion (note that the calvarial hemangioma is a cavernous hemangioma). The tumor is usually well-circumscribed with a highly vascular mural nodule almost always abutting pial layer and a peripheral. Rare central nervous system (CNS) tumours represent a unique challenge. Given the difficulty of conducting dedicated clinical trials, there is a lack of therapies for these tumours supported by high quality evidence, and knowledge regarding the impact of standard treatments (i.e., surgery, radiotherapy or chemotherapy) is commonly based on retrospective studies. Recently, new molecular. 1. Recent Results Cancer Res. 2009;171:3-24. doi: 10.1007/978-3-540-31206-2_1. Astrocytic tumors. Riemenschneider MJ(1), Reifenberger G. Author information: (1)Institute of Neuropathology, University of Düsseldorf, Moorenstr. 5, Düsseldorf 40225, Germany. m.j.riemenschneider@gmx.de Astrocytic gliomas are the most common primary brain tumors and account for up to two thirds of all tumors of.

Granular Cell Astrocytoma: A Diagnostic Conundru

Flotte - Outline of Neurosurgery 7 Malignant Glioma: Anaplastic Astrocytoma & Glioblastoma Clinical • Mean age 60yo • Seziures in 20% Histology • GFAP may be (-) if highly undifferentiated • 3-6% multicentric • CSF seeding occurs in 15%: 2mo survival; consider IT chemo Genetic Each year, in the United States, 4,500 to 5,000 patients are newly diagnosed with a grade II or III astrocytoma or oligodendroglioma. 2 Typically, patients with low-grade gliomas present between 25 and 45 years of age, whereas patients with anaplastic tumors tend to be slightly older. Astrocytoma with IDH-mt is occasionally diagnosed in adolescents (even younger than age 15 years) whereas some.

1 Department of Pathology, Massachusetts General Hospital, Harvard Medical School, WRN225, 55 Fruit Street, Boston, MA 02114, USA both the more common astrocytoma and oligodendroglioma subtypes become more homogeneously defined. In the 2016 CNS WHO, therefore, the prior diagnoses of oligoastrocy-. Astrocytoma originates in astrocytes, which are a kind of glial cells in the cerebrum which are star-shaped. It is the most common glioma, usually affecting the brain and sometimes the spinal cord. Amongst brain tumors, glial tumors comprise 60% of the tumors. They are a common cause of mortality and morbidity in both the young and old both Pilocytic astrocytoma (PA) Approximately 85% of paediatric LGGs are PAs, arising most commonly in the cerebellum, but also in the diencephalon, optic pathways (optic nerve, chiasm, tracts, and radiation), and brainstem 1, 13.PAs presenting in the context of NF-1 arise most often in the optic pathways (66%) 14. About 60-70% of sporadic PAs, especially those in the midline and cerebellum 15. This paper aims to provide an outline of the surgical pathology of the most common tumours of the nervous system in children and adults, and briefly summarise their common genetic changes. The reader is referred to more comprehensive texts for further details about brain tumour classification and the genetic abnormalities of these tumours.1 Most recent classifications of brain tumours build on.

Subependymal giant cell astrocytoma - Libre Patholog

Surgical Pathology Criteria is focused on the presentation of useful diagnostic, grading and staging criteria in an accessible format. The site is designed for use by pathologists in practice. Enter via either of two methods Pathologic findings in surgical resections from patients with temporal lobe epilepsy include a wide range of diagnostic possibilities that can be categorized into different groups on the basis of etiology. This paper outlines the various pathologic entities described in temporal lobe epilepsy, including some newly recognized epilepsy-associated tumors, and briefly touch on the recent.

Introduction. Medulloblastoma (MB) is the most common malignant pediatric brain tumor (), where it accounts for around a quarter of all intracranial neoplasms and around half of posterior fossa tumors ().The majority of MB arise in children with a median age of 9 years, and a peak in incidence between the ages of 3 and 7 years ().However, a second peak is seen in adults accounting for around. Correlation of imaging with pathology can be lacking, however, when a tumor has foci of GBM but is largely composed of lower grade tissue, such as anaplastic astrocytoma or even grade II astrocytoma. Because microscopic infiltration is just that, microscopic, imaging fails to outline the true extent of the tumor Journal of Pathology J Pathol 2017; 241: 159-172 Published online 10 November 2016 in Wiley Online Library (wileyonlinelibrary.com) DOI:10.1002/path.4813 INVITED.

Diffuse Astrocytoma (WHO Grade II) Referred to loosely as well-differentiated, low-grade, diffuse, grade II, or simply astrocytoma, this slow-growing tumor regularly undergoes malignant progression to anaplastic astrocytoma and glioblastoma. Despite often-quoted survivals of 5 to 10 years, a wide range exists among individual patients Primary spinal astrocytoma is a subtype of glioma, the most common spinal cord tumor found in the intradural intramedullary compartment. Spinal astrocytomas account for 6-8% of all spinal cord tumors and are primarily low grade (World Health Organization grade I (WHO I) or WHO II). They are seen in both the adult and pediatric population with the most common presenting symptoms being back pain. Chang S, Zhang P, Cairncross JG, et al. Phase III randomized study of radiation and temozolomide versus radiation and nitrosourea therapy for anaplastic astrocytoma: results of NRG Oncology RTOG 9813. Neuro Oncol 2017; 19:252. Brandes AA, Nicolardi L, Tosoni A, et al. Survival following adjuvant PCV or temozolomide for anaplastic astrocytoma

Pathology Outlines - Anaplastic astrocytoma, IDH wildtype

Gliosis, also called astrocytic gliosis or astrocytosis, is a common term that refers to the reactive astrocytic response to a brain injury or insult. Almost all brain lesions have a component of gliosis, even with different glial pathologies. Gliosis is a secondary event to CNS damage and may persist for weeks or months after brain injury Pathology of Brain tumors (CNS tumors) for undergraduate medical students. Slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising. If you continue browsing the site, you agree to the use of cookies on this website review outlines the clinical, genetic, immunologic, and histopathologic characteristics of astrocytic tumors in dogs with special astrocytoma, biology, classification, dog, genetic Astrocytic tumors in dogs are made up of neoplastic cells that phenotypically resemble astrocytes. The cell of origin of these Veterinary Pathology 48(1) 266-27

Pathology Outlines - Diffuse astrocytic andPathology Outlines - Diffuse astrocytoma NOSPathology Outlines - Pilocytic astrocytoma - grade I

When cysticercosis affects the brain or spinal cord, the condition is called neurocysticercosis. Usually, the cyst causes inflammation in the brain tissue itself which results in a seizure. In about 10% of neurocysticercosis cases, the cysts are found within the cerebral ventricles or in the cerebrospinal fluid spaces (cisterns) (1) Department of Pathology, Duke University Medical Center, Durham, NC, USA Abstract This chapter will introduce the pathology of the optic nerve. Arteritis may result in ischemic damage to the optic nerve (arteritic anterior ischemic optic neuropathy), and therefore, temporal artery biopsy is also discussed here. The optic nerve is a central nerve, no astrocytoma) are slow growing lesions with low-grade histolo-gic features that have a 90% 10-year survival. World Health Organization grade II (diffuse astrocytoma) and III (anaplastic astrocytoma)haveanintermediate prognosisthathasnowbeen shown to largely depend on the underlying molecular signature of the lesion title = Central nervous system gangliogliomas. Part 1: Pathology, abstract = Histopathological features that suggest the diagnosis of ganglioglioma require, in most cases, confirmation by special stains to distinguish these tumors from other gliomas. For this purpose, immunostaining for synaptophysin, which has previously been shown to. CNS Hemorrhage. Germinal matrix hemorrhage with intraventricular hemorrhage in 28 week gestational age newborn, gross. Basal ganglia hemorrhage with hypertension, gross [CT] Basal ganglia hemorrhage with hypertension, gross [CT] Epidural hematoma, gross [CT] Subdural hematoma, acute, gross [CT] Bridging veins from dura, gross